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Updated: May 19, 2026
04:33
Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
Published on: March 12, 2019
Synthetic studies toward (+)-cortistatin A
Zhang Wang1, Mingji Dai, Peter K Park
1Department of Chemistry, Columbia University, Havemeyer Hall, 3000 Broadway, New York, NY 10027.
Tetrahedron
|August 11, 2012
Abstract:
We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus-like cascade sequence culminating in a 6π-electrocyclization, an alkylative dearomatization, and the stereoselective functionalization of the cortistatin A-ring. While the total synthesis we sought was not accomplished, the work sets the stage for several approaches to the preparation of novel analogs via diverted total synthesis.
