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Ex Vivo OCT-Based Multimodal Imaging of Human Donor Eyes for Research into Age-Related Macular Degeneration
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Fine retinal striae associated with epiretinal membrane visualized using adaptive optics.

Susanna S Park1, Stacey S Choi, Robert J Zawadzki

  • 1Department of Ophthalmology & Vision Science, University of California Davis Medical Center, Sacramento.

Retinal Cases & Brief Reports
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Summary

Adaptive optics flood imaging revealed fine retinal striae in a patient with epiretinal membrane (ERM) causing vision loss. These striae, linked to macular traction, resolved after surgery, improving visual acuity.

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Area of Science:

  • Ophthalmology
  • Retinal Imaging
  • Microscopy

Background:

  • Epiretinal membranes (ERMs) can cause vision loss due to macular traction.
  • Assessing microstructural retinal changes in ERM is crucial for understanding vision impairment.

Purpose of the Study:

  • To report on the visualization of fine retinal striae using adaptive optics flood-illuminated (AO-flood) fundus camera.
  • To describe these findings in a patient with vision loss secondary to an idiopathic macular epiretinal membrane (ERM).

Main Methods:

  • A case report detailing a 48-year-old woman with ERM-induced vision loss.
  • Imaging was performed using AO-flood fundus camera and Fourier-domain optical coherence tomography (Fd-OCT) pre- and post-vitrectomy.

Main Results:

  • Post-vitrectomy, visual acuity improved from 20/70 to 20/20.
  • Preoperative Fd-OCT showed cystoid macular edema and outer nuclear layer irregularities.
  • AO-flood en face images revealed dark, linear striae (approx. 10 μm width) overlying the cone mosaic, which improved post-surgery.

Conclusions:

  • AO-flood fundus camera and Fd-OCT can visualize microstructural retinal changes caused by ERM-induced macular traction.
  • These changes may manifest as fine linear striae in AO-flood en face images.
  • Further research is needed to correlate these striae with vision loss in ERM.