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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...

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Related Experiment Video

Updated: May 19, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Motor neurone disease: an overview.

Anna Kent1

  • 1Milton Keynes Community Health Services, Bletchley Community Hospital, Milton Keynes. anna.kent@mkchs.nhs.uk

Nursing Standard (Royal College of Nursing (Great Britain) : 1987)
|August 14, 2012
PubMed
Summary

Motor neurone disease (MND) is a progressive neurological disorder impacting speech, mobility, and breathing. Early palliative and end-of-life care discussions are crucial for holistic patient management.

Area of Science:

  • Neurology
  • Palliative Care
  • Patient Management

Background:

  • Motor neurone disease (MND) is a rare, progressive, and incurable neurological condition.
  • MND significantly impacts patients' speech, mobility, and respiratory function.
  • Care for MND patients is complex, involving multidisciplinary healthcare teams and services.

Purpose of the Study:

  • To highlight the complexity of motor neurone disease care.
  • To emphasize the need for early and continuous symptom management discussions.
  • To advocate for the integration of palliative and end-of-life care from diagnosis.

Main Methods:

  • This study is a review and discussion of current care practices for MND.
  • It synthesizes information on the challenges in managing MND symptoms.

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In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
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In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

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Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices
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Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

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Related Experiment Videos

Last Updated: May 19, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration
06:35

In Vivo Electrophysiological Measurement of Compound Muscle Action Potential from the Forelimbs in Mouse Models of Motor Neuron Degeneration

Published on: June 15, 2018

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices
10:48

Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices

Published on: September 7, 2021

  • It explores the integration of palliative care principles into routine MND management.

    • Main Results:

    • Effective symptom management is essential throughout the disease progression.
    • Holistic care requires addressing physical, emotional, and spiritual needs.
    • Proactive planning for palliative and end-of-life care improves patient and family outcomes.

    Conclusions:

    • Integrated palliative and end-of-life care planning should commence at MND diagnosis.
    • Multidisciplinary collaboration is key to providing comprehensive MND support.
    • Addressing patient needs holistically ensures better quality of life during MND progression.