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Updated: May 19, 2026

A Doxorubicin-Induced Murine Model of Dilated Cardiomyopathy In Vivo
Published on: May 16, 2020
Abstract:
The myocardium have been get from 70 died patients suffered from schizophrenia and treated by neuroleptic drugs. The cardiotoxic effect of neuroleptic drugs was characterized as adaptive, degenerative, and fibrous changes in the miocardium. In the extracellular matrix of the myocardium the processes of microcirculation and the collagenogenesis were damaged. As a result of the using neuroleptic drugs a compensatory hypertrophy of cardiomyocytes was transformed into their degeneration and atrophy that could be reason of a heart failure.
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