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Related Concept Videos

The Mammary Glands01:12

The Mammary Glands

The female breast is a hemispheric projection of variable size positioned anterior to the pectoralis major and serratus anterior muscles. A fascia layer composed of dense, irregular connective tissue connects it to these muscles.
Each breast features a pigmented projection known as the nipple, through which milk emerges via closely spaced openings of ducts, referred to as lactiferous ducts. Surrounding the nipple is a circular pigmented area of skin named the areola, which appears rough due to...

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Related Experiment Video

Updated: May 19, 2026

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
09:49

Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

Published on: November 8, 2014

[Breast silicone granulomas].

S A Povzun

    Arkhiv Patologii
    |August 14, 2012
    PubMed
    Summary

    Silicone leakage from breast implants can cause painful giant cell granulomas and calcified fibrous capsules. These tissue changes around implants persist for up to 12 years.

    Area of Science:

    • Plastic Surgery
    • Biomaterials Science
    • Pathology

    Background:

    • Breast implants, particularly those containing silicone, are widely used in cosmetic and reconstructive surgery.
    • Long-term complications associated with breast implants require thorough understanding for patient safety and improved device design.

    Observation:

    • The study describes the tissue changes occurring around silicone breast implants over time.
    • Observations include the formation of giant cell granulomas and fibrous capsules.
    • Calcification within the fibrous capsule is also noted as a consequence of silicone leakage.

    Findings:

    • Silicone leakage from breast implants is a primary cause of adverse tissue reactions.
    • These reactions manifest as foreign body giant cell granulomas and capsular fibrosis with calcification.

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    Last Updated: May 19, 2026

    Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres
    09:49

    Non-enzymatic, Serum-free Tissue Culture of Pre-invasive Breast Lesions for Spontaneous Generation of Mammospheres

    Published on: November 8, 2014

    Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
    13:35

    Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

    Published on: May 17, 2024

    Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery
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    Tissue-simulating Phantoms for Assessing Potential Near-infrared Fluorescence Imaging Applications in Breast Cancer Surgery

    Published on: September 19, 2014

  • The observed tissue alterations can persist for as long as 12 years post-implantation.

    • Implications:

    • Understanding the long-term tissue response to silicone leakage is crucial for managing implant-related complications.
    • Findings may inform the development of more biocompatible breast implant materials.
    • This research highlights the importance of monitoring patients with breast implants for potential long-term adverse effects.