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Updated: Jun 18, 2025

Modeling Breast Cancer in Human Breast Tissue using a Microphysiological System
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[Breast granular cell tumor].

S A Povzun1, N Yu Novitskaya1

  • 1I.I. Dzanelidze St. Petersburg Scientific Research Institute of Emergency Care, St. Petersburg, Russia.

Arkhiv Patologii
|July 29, 2024
PubMed
Summary
This summary is machine-generated.

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This report details a rare granular cell tumor in the breast, a neoplasm of neuroectodermal origin. Key diagnostic markers include protein S-100 expression and absence of epithelial antigens, distinguishing it from cancer.

Area of Science:

  • Oncology
  • Pathology
  • Radiology

Background:

  • Granular cell tumors (GCTs) are rare neoplasms.
  • GCTs are typically of neuroectodermal origin.
  • Breast localization of GCT is exceptionally uncommon.

Purpose of the Study:

  • To report a case of granular cell tumor in the breast.
  • To outline the differential diagnostic criteria for breast GCT.
  • To highlight imaging characteristics of breast GCT.

Main Methods:

  • Biopsy and histopathological examination.
  • Immunohistochemical analysis for protein S-100, epithelial antigens, histiocytic antigens, oncoproteins, estrogen, and progesterone receptors.
  • Periodic acid-Schiff (PAS) staining.
  • Review of ultrasound and mammography findings.
Keywords:
breastgranular cell tumormicroscopic differential diagnosis

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Main Results:

  • Biopsy confirmed granular cell tumor.
  • Positive cytoplasmic protein S-100 expression.
  • Absence of epithelial and histiocytic antigens, oncoproteins, estrogen, and progesterone receptors.
  • Intracellular granules showed a PAS-positive reaction.
  • Imaging (ultrasound, mammography) initially suggested malignancy or calcification.

Conclusions:

  • Granular cell tumor is a rare breast neoplasm of neuroectodermal origin.
  • Specific immunohistochemical markers are crucial for accurate diagnosis.
  • Radiological findings can mimic breast cancer, necessitating careful histopathological evaluation.