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Related Concept Videos

Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
Regulation of Heart Rates01:31

Regulation of Heart Rates

The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
The SNS increases heart rate through the release of norepinephrine and epinephrine, which act on beta-1 adrenergic receptors in the heart. This action increases the rate of depolarization in the sinoatrial (SA) node, the heart's...
Hormonal Regulation of Blood Pressure01:17

Hormonal Regulation of Blood Pressure

Endocrinal or hormonal intervention in the cardiovascular system is predominantly exerted by the catecholamines - epinephrine and norepinephrine, as well as a slew of hormones that interact with renal function to modulate blood volume.
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Factors Influencing Heart Rate01:30

Factors Influencing Heart Rate

The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...

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Related Experiment Video

Updated: May 19, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Modulation of cardiovascular function by adipokines.

V DeClercq1, J E Enns, A Yeganeh

  • 1Department of Biochemistry & Molecular Biology, Dalhousie University, Halifax, NS, Canada.

Cardiovascular & Hematological Disorders Drug Targets
|August 14, 2012
PubMed
Summary
This summary is machine-generated.

Obesity-related cardiovascular disease risk is linked to dysfunctional adipose tissue and altered adipokine secretion. Targeting specific adipokines like adiponectin offers novel therapeutic strategies for cardiovascular complications.

More Related Videos

Studying Adipose Endothelial Cell/Adipocyte Cross-Talk in Human Subcutaneous Adipose Tissue
06:35

Studying Adipose Endothelial Cell/Adipocyte Cross-Talk in Human Subcutaneous Adipose Tissue

Published on: April 5, 2024

Related Experiment Videos

Last Updated: May 19, 2026

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Studying Adipose Endothelial Cell/Adipocyte Cross-Talk in Human Subcutaneous Adipose Tissue
06:35

Studying Adipose Endothelial Cell/Adipocyte Cross-Talk in Human Subcutaneous Adipose Tissue

Published on: April 5, 2024

Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Research

Background:

  • Cardiovascular disease (CVD) is a major health concern, with obesity as a significant risk factor.
  • Adipose tissue functions as an endocrine organ, becoming dysfunctional and altering adipokine secretion with increased mass.
  • Abdominal adiposity leads to endocrine imbalances, potentially increasing CVD risk.

Purpose of the Study:

  • To review the latest developments in therapeutic targets within adipose tissue.
  • To discuss the role of specific adipokines in obesity-related cardiovascular complications.

Main Methods:

  • Literature review of recent research on adipokines and cardiovascular disease.
  • Focus on adipokines including adiponectin, CTRPs, visfatin, vaspin, chemerin, and omentin.

Main Results:

  • Dysfunctional adipose tissue in obesity alters adipokine profiles.
  • Specific adipokines are implicated in the pathogenesis of obesity-related cardiovascular complications.
  • Adipose tissue proteins represent potential therapeutic targets.

Conclusions:

  • Adipokines play a critical role in the link between obesity and cardiovascular disease.
  • Targeting specific adipokines may offer novel therapeutic avenues for preventing or treating cardiovascular complications.
  • Further research into disease-specific proteins in adipose tissue is warranted for therapeutic development.