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Trigger finger, tendinosis, and intratendinous gene expression
A-C Lundin1, P Aspenberg, P Eliasson
1Department of Hand Surgery, Plastic Surgery and Burns, Linkoping University Hospital, Linkoping, Sweden.
Scandinavian Journal of Medicine & Science in Sports
|August 14, 2012
Summary
Trigger finger may be a form of tendinosis, similar to Achilles tendinosis. Gene expression in trigger finger tendons shows significant changes, supporting this tendinosis hypothesis.
Area of Science:
- Orthopedics
- Molecular Biology
- Rheumatology
Background:
- Trigger finger pathogenesis traditionally linked to annular ligament changes.
- Recent findings suggest tendon pathology in trigger finger, akin to Achilles tendinosis.
Purpose of the Study:
- To investigate gene expression differences in trigger finger tendons compared to healthy tendons.
- To determine if trigger finger exhibits a gene expression pattern similar to Achilles tendinosis.
Main Methods:
- Quantitative real-time polymerase chain reaction (PCR) on finger flexor tendon biopsies.
- Analysis of 10 specific genes previously associated with tendinosis in 13 trigger fingers and 13 controls.
Main Results:
- Significant upregulation of collagen types 1a1 and 3a1, aggrecan, and biglycan in trigger finger tendons.
- Significant downregulation of matrix metalloproteinase-3 (MMP-3) and tissue inhibitor of metalloproteinase-3 (TIMP-3).
- Observed gene expression changes mirror those found in Achilles tendinosis.
Conclusions:
- Gene expression patterns support the hypothesis that trigger finger is a tendinosis.
- Findings suggest trigger finger may serve as a model for tendinosis research, potentially impacting surgical treatments.
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