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Merkel Cell Polyomavirus Infection and Detection
Published on: February 7, 2019
Kodamaea ohmeri isolate from two immunocompromised patients: first report in Italy
1Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy. iolanda.santino@uniroma1.it
Mycoses
|August 14, 2012
Summary
Kodamaea ohmeri, a yeast-form fungus, is increasingly causing serious infections in immunocompromised individuals. This study reports two new cases in Italy, detailing identification and successful antifungal susceptibility.
Area of Science:
- Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Kodamaea ohmeri is an emerging fungal pathogen causing severe infections like fungemia and endocarditis, particularly in immunocompromised patients.
- The increasing prevalence of opportunistic fungal infections necessitates detailed characterization of etiological agents.
Observation:
- Two new isolates of Kodamaea ohmeri were identified in immunocompromised patients.
- Identification methods included CHROMagar Candida medium, VitekII system, API ID32C, and 26S ribosomal DNA sequencing.
Findings:
- The isolates demonstrated susceptibility to key antifungal drugs: amphotericin B, voriconazole, and itraconazole.
- Biochemical and molecular analyses confirmed the yeast's identity.
Implications:
- This study marks the first report of Kodamaea ohmeri isolation in immunocompromised patients in Italy.
- Findings contribute to understanding the geographic spread and clinical significance of this opportunistic pathogen.
- Susceptibility data informs potential therapeutic strategies against Kodamaea ohmeri infections.
