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Updated: May 19, 2026

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
Published on: January 30, 2020
A life-threatening flecainide overdose treated with intravenous fat emulsion
Heather Ellsworth1, Samuel J Stellpflug, Jon B Cole
1Department of Emergency Medicine, Regions Hospital, St. Paul, MN 55101, USA. heatherellsworth9@gmail.com
Abstract:
Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life-threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life-threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life-threatening toxicity following flecainide overdose.
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