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Published on: August 6, 2019
IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia.
P Linhartova1, P Cernochova, L Izakovicova Holla
1Department of Pathophysiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Oral Diseases
|August 14, 2012
Summary
Interleukin 1 gene variants, specifically IL1RN VNTR, may be linked to external apical root resorption (EARR) risk in orthodontic patients, particularly girls. Further research is needed to confirm these findings for EARR development.
Area of Science:
- Genetics
- Orthodontics
- Periodontology
Background:
- External apical root resorption (EARR) is a common complication of orthodontic treatment, leading to permanent tooth root shortening.
- Genetic factors, including polymorphisms in the interleukin 1 (IL1) gene cluster, are suspected to influence EARR susceptibility.
- Understanding these genetic associations can aid in identifying individuals at higher risk.
Purpose of the Study:
- To investigate the association between specific gene variants within the IL1 gene cluster and the risk of developing EARR.
- To analyze IL1A, IL1B, and IL1RN gene polymorphisms in a Czech population cohort undergoing orthodontic treatment.
- To determine if any identified gene variants are specifically linked to EARR in different demographic subgroups, such as girls.
Main Methods:
- A case-control study design was employed, comparing 32 patients diagnosed with EARR to 74 control subjects.
- Genotyping was performed using PCR-based methods to analyze polymorphisms in IL1A (-889C/T), IL1B (+3953C/T), and IL1RN (VNTR).
- Statistical analyses were conducted to compare genotype, allele, and haplotype frequencies between EARR patients and controls, with subgroup analysis for gender.
Main Results:
- No statistically significant differences were found in the frequencies of IL1A and IL1B gene variants or reconstructed haplotypes between EARR patients and controls.
- Marginal significance was observed for the IL1RN variant, specifically the *22 genotype (P=0.05) and the short (2) allele (P=0.06).
- Significant associations were identified between IL1RN genotypes (*12, *22) and the short (2) allele and EARR in the subgroup of girls (P=0.04, P=0.02, P=0.02).
Conclusions:
- The study did not confirm a significant role for IL1A (-889C/T) and IL1B (+3953C/T) gene variants in the development of EARR.
- The IL1RN VNTR polymorphism shows a potential association with EARR, particularly in female orthodontic patients.
- These findings suggest that IL1RN genetic variations may contribute to EARR susceptibility, warranting further investigation, especially in specific populations and genders.
