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Genetic determinants and postorthodontic external apical root resorption in Czech children
P Borilova Linhartova1,2, P Cernochova1, J Kastovsky3
1Clinic of Stomatology, Institutions Shared with St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Oral Diseases
|August 6, 2016
Summary
Genetic variations in the P2RX7 gene and longer orthodontic treatment duration may increase the risk of external apical root resorption (EARR) in children. Further research is needed to confirm these findings in diverse populations.
Area of Science:
- Genetics
- Orthodontics
- Immunology
Background:
- External apical root resorption (EARR) is a common complication of orthodontic treatment.
- Genes modulating inflammation and bone remodeling are implicated in EARR development.
Purpose of the Study:
- To investigate the association between seven single nucleotide polymorphisms (SNPs) in IL-17A, SPP1, P2RX7, and TNFRSF11B genes and EARR in orthodontically treated children.
- To explore the role of genetic variability and treatment duration in the etiopathogenesis of postorthodontic EARR.
Main Methods:
- Case-control study involving 99 patients (30 with EARR, 69 controls).
- Genotyping of seven SNPs (rs2275913, rs11730582, rs9138, rs208294, rs1718119, rs3102735, rs2073618) using TaqMan assays.
- Analysis of allele, genotype, and haplotype frequencies, and correlation with treatment duration.
Main Results:
- No significant association was found between individual SNPs and EARR risk.
- A specific haplotype in the P2RX7 gene (rs208294 and rs1718119) was associated with increased EARR risk (P < 0.05).
- Longer duration of fixed orthodontic appliance treatment correlated positively with EARR development (P < 0.05).
Conclusions:
- Individual SNPs in the studied genes were not confirmed as risk factors for EARR in the Czech population.
- Variability in the P2RX7 gene and extended orthodontic treatment duration are suggested as contributing factors to postorthodontic EARR.
- Further investigation into complex genetic and environmental interactions is warranted.
