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Updated: May 19, 2026
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FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Trisomy 8 in myeloid leukemia cutis confirmed by fluorescence in situ hybridization analysis
Marianna Shvartsbeyn1, Shane M Meehan, Ping Gu
1Department of Pathology, New York University School of Medicine, New York, NY 10016, USA. Marianna.Shvartsbeyn@nyumc.org
Journal of Cutaneous Pathology
|August 14, 2012
Abstract:
We present a case of a 64-year-old man with refractory acute myeloid leukemia and trisomy 8 who developed leukemia cutis. Interphase fluorescence in situ hybridization (FISH) was performed on a paraffin-embedded skin section. FISH confirmed a population of cells with trisomy 8 in the blastic infiltrates involving the skin. This case illustrates a novel application of interphase FISH to confirm the diagnosis of leukemia cutis.
