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An opiate receptor on frog sciatic nerve axons.

E G Hunter, G B Frank

    Canadian Journal of Physiology and Pharmacology
    |October 1, 1979
    PubMed
    Summary
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    Meperidine affects nerve action potentials by altering amplitude and depolarization rates. Naloxone partially blocks these effects, indicating both local anesthetic and opiate receptor mechanisms.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Meperidine is an opioid analgesic with known central nervous system effects.
    • Understanding its peripheral nerve effects is crucial for its clinical application.

    Purpose of the Study:

    • To investigate the electrophysiological effects of meperidine on frog sciatic nerve action potentials.
    • To elucidate the mechanisms underlying meperidine's actions on nerve conduction.

    Main Methods:

    • The double sucrose gap technique was employed to record action potentials.
    • Frog sciatic nerves were exposed to meperidine (3 X 10(-4) M) and naloxone (1 X 10(-8) M).

    Main Results:

    • Meperidine significantly decreased action potential amplitude, maximum depolarization rate, and repolarization rate.

    Related Experiment Videos

  • Resting potential remained unaffected by meperidine.
  • Naloxone partially antagonized the amplitude and maximum rate of rise depression but further decreased the maximum rate of depolarization.

    • Conclusions:

    • Meperidine exerts its effects on peripheral nerves through a dual mechanism.
    • These mechanisms include a non-specific local anesthetic-like action and an opiate receptor-mediated effect.