[Association between serum uric acid and short-term clinical outcome among patients with acute stroke]

To investigate the association between serum uric acid (SUA) and early clinical outcome among patients with acute stroke.

A total of 3231 acute stroke patients were included in the present study. Data on demographic characteristics, life style risk factors, history of disease, admission SUA and clinical outcome at discharge were collected for all participants. Poor clinical outcome was defined as neurologic deficiency (NIHSS≥10) at discharge or death during hospitalization.

Increased SUA level was associated with decreased risk of poor outcome among ischemic stroke patients. After adjustment for multivariate, the odds ratio (95% confidence interval) of poor outcome for every increased unit was 0.856 (0.795-0.898) among ischemic stroke patients. Logistic analysis was conducted according to quintile of SUA level, after adjustment for multi-variates, the odds ratio (95% confidence interval) of poor clinical outcome appeared to be associated with SUA of 197-241 µmol/L, 242-285 µmol/L, 286-346 µmol/L and ≥347 µmol/L, but were 0.552 (0.354-0.861), 0.417 (0.263-0.661), 0.390 (0.241-0.630) and 0.352 (0.213-0.581), respectively in those acute ischemic stroke patients, when compared to those with SUA<197 µmol/L. Among acute hemorrhagic stroke patients, after adjustment for multivariate, the odds ratio (95% confidence interval) of poor outcome for every increased unit was not significant among hemorrhagic stroke patients. According to the quintile of SUA level, when compared to those with SUA<150 µmol/L, the odds ratio (95% confidence interval) of poor clinical outcomes associated with SUA of 150-185 µmol/L, 186-230 µmol/L, 231-297 µmol/L and ≥298 µmol/L, were also not significant among those hemorrhagic stroke patients.

Elevated SUA seemed to be an independent predictor for short-term good clinical outcome among acute ischemic stroke patients.