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[Paediatric meningococcal meningitis in France: ACTIV/GPIP network results]

C Levy1, M-K Taha, E Bingen

  • 1GPIP-Groupe de Pathologie Infectieuse Pédiatrique de la SFP-Société Française de Pédiatrie, France. activ@wanadoo.fr

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|August 14, 2012
PubMed
Abstract

Insights

Meningococcal meningitis remains a significant threat, particularly in children under five. Vaccination against serogroups B and C is crucial for controlling this disease.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Microbiology

Background:

  • An active surveillance network was established to analyze meningococcal meningitis.
  • The network focused on epidemiological, clinical, and biological features of the disease.

Purpose of the Study:

  • To analyze the epidemiological, clinical, and biological features of meningococcal meningitis in children.
  • To assess the impact of vaccination on meningococcal meningitis cases.

Main Methods:

  • Data collected from French pediatric wards and 166 microbiology laboratories.
  • Included risk factors, symptoms, vaccination status, CSF analysis, treatments, and case fatality rates for bacterial meningitis cases in children (0-18 years).

Main Results:

  • 1661 cases of meningococcal meningitis reported between 2001 and 2009 (44.1% of bacterial meningitis).
  • Serogroup B (61.3%) was most prevalent, followed by serogroup C (27.0%).
  • No serogroup C cases in vaccinated children; 6.5% global case fatality rate, higher for serogroup C (9.2%) than B (5.9%).

Conclusions:

  • Meningococcal bacteria cause approximately 50% of meningitis cases in France.
  • Effective serogroup B and C vaccines could significantly reduce the burden of meningococcal meningitis.
  • This study represents one of the largest series of microbiologically documented meningococcal meningitis cases.

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