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Operating Transverse Aortic Constriction with Absorbable Suture to Obtain Transient Myocardial Hypertrophy
Published on: September 9, 2020
[Surgical treatment with modified Morrow procedure in hypertrophic obstructive cardiomyopathy]
Chang-qing Gao1, Chong-lei Ren, Cang-song Xiao
1Department of Cardiovascular Surgery, Institute of Cardiac Surgery of People's Liberation Army, People's Liberation Army General Hospital, Beijing 100853, China. gaochq301@yahoo.com
Insights
The modified Morrow procedure effectively reduces left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy (HOCM) patients. This surgery significantly improves symptoms and reduces the hypertrophied septum, offering a successful treatment option.
Area of Science:
- Cardiovascular Surgery
- Cardiology
- Cardiac Anatomy
Context:
- Hypertrophic obstructive cardiomyopathy (HOCM) presents a significant clinical challenge due to left ventricular outflow tract (LVOT) obstruction.
- Systolic anterior motion (SAM) of the mitral valve and mitral regurgitation are common complications in HOCM.
- The modified Morrow procedure, a type of ventricular septal myectomy, is employed to address these issues.
Purpose:
- To evaluate the efficacy and outcomes of the modified Morrow procedure in patients diagnosed with HOCM.
- To assess the impact of ventricular septal myectomy on LVOT gradient, septal thickness, and associated symptoms.
Summary:
- Thirty-eight HOCM patients underwent ventricular septal myectomy (modified Morrow procedure) between June 2003 and March 2011.
- Preoperative mean LVOT gradient of 89±31 mmHg decreased significantly to 18±13 mmHg post-surgery (1-2 weeks).
- The procedure effectively resolved or improved SAM and mitral regurgitation, leading to asymptomatic status in all patients post-follow-up.
Impact:
- The modified Morrow procedure demonstrates high effectiveness in managing HOCM, significantly reducing LVOT obstruction.
- Successful surgery relies on adequate surgical exposure and complete resection of the hypertrophied septum.
- Patients experience substantial symptomatic relief, including abolition of syncope and improvement in dyspnea.
Objective:
To summarize the experience of ventricular septal myectomy (modified Morrow procedure) in patients with hypertrophic obstructive cardiomyopathy (HOCM).
Methods:
From June 2003 to March 2011, 38 patients (26 male and 12 female) with HOCM underwent modified Morrow procedure. The mean age was 36.3 years (ranging from 18 to 64 years). The diagnosis was made by echocardiography and spiral CT. The mean systolic gradient between the left ventricle and the aorta from transthoracic echocardiography (TTE) was (89±31) mmHg (ranging from 50 to 184 mmHg, 1 mmHg=0.133 kPa) before operation. There was moderate or severe systolic anterior motion (SAM) in 38 cases and mitral regurgitation in 29 cases. Ventricular septal myectomy with modified Morrow procedure was performed in all 38 cases. TEE was used intraoperatively to evaluate the results of the surgical procedures. After 1 to 2 weeks of operation, TTE was performed to evaluate the effect of operation. All patients were followed up with TTE after operation.
Results:
All patients were discharged without complications. Intraoperative TEE showed that the mean systolic gradient between the left ventricle and the aorta was decreased from (95±36) mmHg before procedures to (14±11) mmHg after operation (t=13.265, P=0.000), and the thickness of ventricular septum was decreased from (28±8) mm to (12±3) mm (t=11.656, P=0.000). TTE showed that the mean systolic gradient between the left ventricle and the aorta was decreased from (89±31) mmHg preoperatively to (18±13) mmHg (t=12.729, P=0.000) in 1 to 2 weeks after operation. Mitral regurgitation and SAM were significantly improved or disappeared (t=7.930, t=5.213, both P=0.000). During the follow-up, all patients promptly became completely asymptomatic or complained of mild effort dyspnea only and syncope was abolished, and TTE showed that the pressure gradient was kept on the postoperative level or slightly decreased (P=0.494).
Conclusions:
Ventricular septal myectomy with modified Morrow procedure is a mostly effective method for patients with HOCM. Good surgical exposure and the hypertrophied septum thoroughly excised are paramount for successful surgery.
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