Related Experiment Video
Updated: Aug 17, 2026

Integrated Compensatory Responses in a Human Model of Hemorrhage
Published on: November 20, 2016
[The mechanisms of hemodynamic shifts in normovolemic hemodilution]
Abstract:
Normovolemic hemodilution is shown to activate adaptation mechanisms of the heart, regional circulation and microvasculature. This is accompanied by a decline in the total peripheral resistance, an increase in venous return and intensification of the regional tissue blood flow. An increase in the cardiac output is due to mobilization of the functional cardiac reserve and is not accompanied by intensification of the heart work. Accelerated pulmonary circulation in normovolemic hemodilution may lead to functional shunting and blood oxygenation disturbances in patients with anatomic and functional respiratory changes.
Related Concept Videos
Hypertension and Regulation of Blood Pressure
Hormonal Regulation of Blood Pressure
Epinephrine and Norepinephrine
The adrenal medulla releases epinephrine and norepinephrine, catecholamines that enhance and extend the sympathetic or "fight or flight" physiological response. These hormones escalate heart rate and the force of contraction while...
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Blood Pressure Imbalances and Circulatory Shock
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Fluid Movement Between Compartments
Heart Failure II: Pathophysiology

