[The 2,3-diphosphoglycerate content and its influence on hemoglobin-oxygen affinity in patients following open heart...

70 patients have been examined in the early postoperative period after aortocoronary bypass surgery and surgical correction of acquired heart valve defects. 2,3-diphosphoglycerate (DPG) concentration was shown to increase in acute postoperative disturbances. The increase was most pronounced in reduced oxygen transport to tissues. However, with 2,3-DPG synthesis and metabolism slowed down, its concentration did not always correspond to the real state of the cardio-respiratory system. Changes in H+ concentration played a certain role in the regulation of 2,3-DPG content. In patients with cardio-respiratory disturbances 2,3-DPG concentration increased by 0.55 mcM/ml on average, with plasma pH increased by 0.1. No such regularity has been observed in patients with uncomplicated postoperative period. A positive correlation has been established between changes in 2,3-DPG concentration and the position of oxyhemoglobin dissociation curve. Considerable fluctuations in P50 value standard in cardiorespiratory disturbances have been observed. However 2,3-DPG effect was not the only mechanism causing these fluctuations.