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Related Experiment Video

Updated: May 19, 2026

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

A new paradigm for calculating skin dose.

Kent A Gifford¹, Omar Pacha, Adelaide A Hebert

¹Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. kagifford@mdanderson.org

|August 14, 2012

Summary

The volumetric skin model accurately represents breast epidermal thickness, unlike surface models which may underestimate radiation dose. This difference is crucial for accurate treatment planning and toxicity assessment in accelerated partial breast irradiation.

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Published on: March 11, 2021

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Last Updated: May 19, 2026

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Diffuse Optical Spectroscopy for the Quantitative Assessment of Acute Ionizing Radiation Induced Skin Toxicity Using a Mouse Model

Published on: May 27, 2016

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

Area of Science:

Radiation Oncology
Medical Physics
Dermatology

Background:

Current breast epidermis modeling in radiation therapy often uses a surface contour.
This approach may not accurately reflect the true skin thickness, potentially impacting dose calculations.

Purpose of the Study:

To compare a volumetric skin model with the conventional external surface contour (ext) model.
To evaluate their accuracy in radiation treatment planning for accelerated partial breast irradiation (APBI) brachytherapy.

Main Methods:

Literature review to determine average breast epidermal thickness.
Clinical APBI plans were created using two skin models: a 2-mm contracted external contour and a 5-mm expanded contour.
Maximum doses were recorded and compared between the two models.

Main Results:

Average breast epidermal thickness was found to be 1.68 mm.
The surface model (ext+5mm) showed mean dose differences of 10.1% (balloon), 14.5% (strut), and 12.5% (all plans) compared to the volumetric model.
These dose differences were statistically significant (p<0.0001).

Conclusions:

The volumetric skin model is validated by the measured epidermal thickness.
Surface models may underestimate epidermal dose by up to 23.8%.
Inaccurate skin modeling can skew correlations between radiation dose and toxicity.