Related Experiment Video
Updated: May 19, 2026

Investigating Drivers of Antireward in Addiction Behavior with Anatomically Specific Single-Cell Gene Expression Methods
Published on: August 4, 2022
Effectiveness of a brief integrative multiple substance use intervention among young men with and without booster
Gerhard Gmel1, Jacques Gaume, Nicolas Bertholet
1Alcohol Treatment Centre, Lausanne University Hospital CHUV, Mont-Paisible 16, CH - 1011 Lausanne, Switzerland. Gerhard.Gmel@chuv.ch
Abstract:
Brief interventions (BI) commonly employ screening and target a single substance. Multi-substance interventions are a more adequate reflection of risk behaviors in adolescents and young adults. Systematic screening complicates BI in many settings. The effectiveness of a voluntary multi-substance intervention among 19-year-old men and the incremental impact of booster sessions were analyzed. Participants were enrolled during mandatory army conscription in Switzerland. Compared with 461 controls, 392 BI subjects showed reduced substance use on 10 of 12 measures (4 tobacco, 4 cannabis, and 2 alcohol measures). Between-group effects were small and non-significant (except for cannabis use prevalence). Three-month booster sessions were not effective and even contraindicated. The usefulness of targeting multi-substances during BIs without prior screening depends on the value of small effects. The addition of booster sessions was not effective and therefore is not recommended.
Related Concept Videos
Community Based Intervention
Foundations of Community Mental Health Programs
Central to the success of community-based interventions is the...
Dosage Regimens: Designs and Approaches
Bioavailability Study Design: Single Versus Multiple Dose Studies
Drug Dependence
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions
Combined Effects of Drugs: Synergism
Such synergistic combinations...
