A disposable paper-based electrochemical sensor with an addressable electrode array for cancer screening.

Area of Science:

• Electroanalytical Chemistry
• Materials Science
• Sensor Technology

Background:

• Development of cost-effective and portable sensing platforms is crucial.
• Paper-based devices offer advantages in low cost, flexibility, and disposability.
• Integration of addressable electrodes on paper substrates presents fabrication challenges.

Purpose of the Study:

• To develop a novel, addressable electrode array using paper as the substrate.
• To demonstrate a facile fabrication method for a 4x6 sensor array.
• To integrate sensing sites, counter electrodes, and reference electrodes onto a paper platform.

Main Methods:

• Assembly of a 4x6 sensor array using a home-made device holder.
• Utilizing two layers of paper: one for sensing sites, the other for printed electrodes.
• Positioning of row/column electrodes at crossing points to form the addressable array.
• Printing of counter and reference electrodes on a separate paper layer.

Main Results:

• Successful fabrication of a 4x6 addressable electrode array on a paper substrate.
• Demonstration of a facile and low-cost assembly process.
• Integration of all necessary electrode components (sensing, counter, reference) within the paper-based device.

Conclusions:

• A novel paper-based addressable electrode array was successfully developed.
• The facile fabrication method enables the creation of integrated sensing platforms.
• This approach holds potential for developing low-cost electrochemical sensors.