Related Experiment Video
Updated: May 19, 2026

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat
Published on: August 28, 2021
Dexmedetomidine for transport of a spontaneously breathing combative child
Kevin M Watt1, Jason Walgos, Ira M Cheifetz
1Division of Pediatric Critical Care, Department of Pediatrics, Duke University Medical Center, Box 3046, Durham, NC 27710, USA.
Insights
Pediatric interhospital transport requires careful airway management. Dexmedetomidine offers a sedation option for agitated children, potentially avoiding intubation and mechanical ventilation during transport.
Area of Science:
- Pediatric Emergency Medicine
- Pediatric Critical Care
- Pharmacology
Background:
- Interhospital transport of children presents significant airway management challenges.
- Agitated children without respiratory compromise pose a dilemma due to risks of respiratory depression with sedatives.
- Intubation provides airway control but carries risks, especially with limited resources.
Abstract:
Interhospital transport presents a challenge for pediatricians, and airway protection is often a significant concern. The severely agitated child without respiratory compromise poses an extremely difficult dilemma, as most sedative agents can cause respiratory depression. Intubation offers definitive control of the airway but is not without risk, especially in an environment where experience and resources for pediatric intubation may be limited. Dexmedetomidine may be used for sedation in certain circumstances for the transport of a child without the need for intubation and mechanical ventilation.
Related Concept Videos
Parenteral Anesthetics: Overview
Drug Delivery: Enteral Route
Drugs in...
Skeletal Muscle Relaxants: Therapeutic Uses
Inhalational Anesthetics: Overview
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Drug Dosing: Infants and Children

