Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 19, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
07:44

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Published on: April 24, 2016

Submandibular gland-sparing intensity-modulated radiotherapy.

William M Mendenhall1, Charles M Mendenhall, Nancy P Mendenhall

  • 1*Department of Radiation Oncology, University of Florida College of Medicine, Gainesville, FL †Phoebe Putney Memorial Hospital, Albany, GA.

American Journal of Clinical Oncology
|August 16, 2012
PubMed
Summary

Intensity-modulated radiotherapy (IMRT) sparing the submandibular gland (SMG) may reduce xerostomia after head and neck radiation. This technique shows promise for improving patient quality of life without compromising cancer treatment outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perirectal spacers and endorectal balloons in external beam radiotherapy for prostate cancer: a review of prospective studies.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2026
Same author

Robust Four-Field and Arc LET-Optimized Proton Prostate Cancer Treatment Plans With Urethral Sparing.

International journal of particle therapy·2026
Same author

Particle Therapy Co-Operative Group Consensus Statement on Reirradiation With Proton Therapy for Prostate Cancer.

International journal of particle therapy·2026
Same author

Ten-year outcomes for image-guided moderately hypofractionated proton therapy for prostate cancer.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Comparing Organs at Risk Sparing Between Intensity-Modulated Radiotherapy and Pencil-Beam Scanning Plans Based on Disease Location for Hodgkin and Non-Hodgkin Lymphoma.

International journal of particle therapy·2026
Same author

Management of a Multi-Room Downtime Event in a Multi-System Environment: A Case Report in Proton Therapy Operations.

International journal of particle therapy·2026

Area of Science:

  • Oncology
  • Radiotherapy
  • Salivary Gland Physiology

Background:

  • Xerostomia (dry mouth) is a debilitating side effect of head and neck radiotherapy (RT).
  • The submandibular gland (SMG) is crucial for saliva production, contributing significantly to daily salivary flow.
  • Current RT techniques like intensity-modulated RT (IMRT) aim to spare parotid glands but have limited data on SMG sparing.

Purpose of the Study:

  • To evaluate the efficacy and safety of SMG-sparing IMRT in head and neck cancer patients.
  • To assess the impact of SMG-sparing IMRT on long-term xerostomia and salivary function.
  • To determine if SMG-sparing IMRT affects local-regional recurrence rates.

Main Methods:

  • Review of existing literature and clinical experience with SMG-sparing IMRT.

More Related Videos

Retroductal Nanoparticle Injection to the Murine Submandibular Gland
07:45

Retroductal Nanoparticle Injection to the Murine Submandibular Gland

Published on: May 3, 2018

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation
09:10

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation

Published on: May 4, 2018

Related Experiment Videos

Last Updated: May 19, 2026

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction
07:44

Retroductal Submandibular Gland Instillation and Localized Fractionated Irradiation in a Rat Model of Salivary Hypofunction

Published on: April 24, 2016

Retroductal Nanoparticle Injection to the Murine Submandibular Gland
07:45

Retroductal Nanoparticle Injection to the Murine Submandibular Gland

Published on: May 3, 2018

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation
09:10

Murine Salivary Functional Assessment via Pilocarpine Stimulation Following Fractionated Radiation

Published on: May 4, 2018

  • Analysis of RT doses delivered to the SMG and their correlation with salivary flow.
  • Comparison of xerostomia rates and recurrence data between patients receiving standard IMRT and SMG-sparing IMRT.

    • Main Results:

    • Mean RT doses to the SMG above 39 Gy are associated with permanent loss of salivary function.
    • Limited data suggest SMG-sparing IMRT can reduce long-term xerostomia in selected patients.
    • SMG-sparing IMRT has not shown an increased risk of local-regional recurrence.

    Conclusions:

    • SMG-sparing IMRT is a viable strategy for mitigating xerostomia in head and neck cancer patients.
    • Preserving SMG function through targeted IMRT can significantly improve quality of life.
    • Further research is warranted to establish optimal protocols for SMG-sparing IMRT.