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Related Concept Videos

Development of the Heart01:27

Development of the Heart

The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Zygotic Development And Stem Cell Formation01:10

Zygotic Development And Stem Cell Formation

The development of all multicellular organisms starts with the fusion of haploid cells called sperm and egg to form a diploid zygote. A zygote is a totipotent cell that can develop into a complete organism. The zygote undergoes cell division or cleavage to form an 8-cell mass. Until this stage, the cells are spherical, loosely attached, and remain totipotent. Totipotent cells are capable of developing both the embryonic and the extraembryonic tissues. However, as they continue to divide, they...
Embryonic Stem Cells00:58

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

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Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
08:00

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

Early cardiac development: a view from stem cells to embryos.

Patrick Van Vliet1, Sean M Wu, Stéphane Zaffran

  • 1Skaggs School of Pharmacy and Pharmaceutical Sciences, UCSD, CA, USA.

Cardiovascular Research
|August 16, 2012
PubMed
Summary

Early heart development research uses chick and mouse embryos, and now human embryonic stem cells (ESCs). These models reveal genetic and epigenetic regulation of cardiac cell fate decisions.

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Cardiovascular Research

Background:

  • Early cardiac development has been studied since the 1920s using chick and mouse embryos.
  • Human embryonic stem cells (ESCs) have emerged as a powerful model for studying early cardiogenesis.
  • Understanding cell fate decisions in endocardium, myocardium, and epicardium is crucial.

Purpose of the Study:

  • To review biological concepts of cell fate decisions in early cardiogenesis.
  • To highlight the role of model organisms and ESCs in cardiac development research.
  • To emphasize the ongoing contribution of in vitro stem cells to the field.

Main Methods:

  • Review of pioneering and recent studies on cardiac development.
  • Analysis of research utilizing chick and mouse embryos.
  • Examination of studies employing human embryonic stem cells (ESCs).

Main Results:

  • Embryonic stem cells (ESCs) faithfully recapitulate early cardiogenesis.
  • Human ESCs provide a unique model for studying genetic and epigenetic regulation.
  • Model organisms and ESCs have significantly advanced understanding of cardiac development.

Conclusions:

  • In vitro stem cells continue to play a vital role in cardiac developmental biology.
  • Research in model organisms and ESCs has elucidated key cell fate decisions.
  • Continued investigation is essential for a comprehensive understanding of early heart formation.