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Updated: May 19, 2026
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Corneal collagen cross-linking window absorption
Pietro Rosetta1, Riccardo Vinciguerra, Mario R Romano
1Department of Ophthalmology, Istituto Clinico Humanitas, Milan, Italy.
Purpose:
To evaluate the safety and efficacy of treatment of severe infectious corneal ulcers with hypoosmolar riboflavin solution and UV-A collagen cross-linking (CXL) without deepithelizing the cornea.
Methods:
Four eyes of 3 patients with severe keratitis and associated corneal melting, were treated with a new protocol of corneal CXL for infectious keratitis, named cross-linking window absorption (CXL-WA). CXL-WA was performed when the infection did not respond to systemic and topical antibiotic therapy. The protocol entails the use of hypoosmolar riboflavin before the irradiation with UV-A, and the penetration is obtained through the epithelial defect overlying the ulcer.
Results:
In all cases, CXL halted the progression of the ulcer. After a minimum follow-up of 3 months, none of the patients had recurrence of the infection.
Conclusion:
CXL-WA is a promising technique of treatment of infectious corneal ulcers, delaying or preventing more invasive approaches.
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