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Related Experiment Video

Updated: May 19, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

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Corneal collagen cross-linking window absorption.

Pietro Rosetta1, Riccardo Vinciguerra, Mario R Romano

  • 1Department of Ophthalmology, Istituto Clinico Humanitas, Milan, Italy.

Cornea
|August 17, 2012
PubMed
Summary
This summary is machine-generated.

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Hypoosmolar riboflavin and UV-A collagen cross-linking (CXL) without debridement safely treated severe infectious corneal ulcers. This cross-linking window absorption (CXL-WA) method halted ulcer progression and prevented recurrence in all patients.

Area of Science:

  • Ophthalmology
  • Microbiology

Background:

  • Severe infectious keratitis with corneal melting poses a significant threat to vision.
  • Standard antibiotic therapy may be insufficient for aggressive microbial keratitis.

Observation:

  • A novel protocol, cross-linking window absorption (CXL-WA), was employed for severe infectious keratitis unresponsive to antibiotics.
  • This technique utilizes hypoosmolar riboflavin and UV-A irradiation without corneal debridement, targeting the ulcer through its epithelial defect.

Findings:

  • Corneal collagen cross-linking (CXL-WA) effectively halted ulcer progression in all treated eyes.
  • No recurrence of infection was observed during a minimum 3-month follow-up period.
  • The procedure demonstrated safety and efficacy in managing severe infectious corneal ulcers.

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Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
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Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

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Last Updated: May 19, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking (TXL) for Myopia
12:25

Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking (TXL) for Myopia

Published on: January 6, 2018

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
05:56

Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model

Published on: April 3, 2016

Implications:

  • CXL-WA presents a promising, less invasive alternative for treating infectious corneal ulcers.
  • This approach may help avert the need for more aggressive surgical interventions.
  • Further research into CXL-WA could refine treatment strategies for microbial keratitis.