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Study protocol: EXERcise and cognition in sedentary adults with early-ONset dementia (EXERCISE-ON)
Astrid M Hooghiemstra1, Laura H P Eggermont, Philip Scheltens
1Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands. a.m.hooghiemstra@vu.nl
BMC Neurology
|August 18, 2012
Summary
This study investigates if exercise can slow symptom progression in early-onset dementia patients. Researchers aim to determine exercise
Area of Science:
- Neurology
- Gerontology
- Rehabilitation Medicine
Background:
- Early-onset dementia presents significant challenges for patients and families, with limited non-pharmacological interventions available.
- Exercise interventions have shown cognitive benefits in older adults without dementia and those at risk.
- Patients with early-onset dementia, due to their younger age, may be suitable candidates for structured exercise programs.
Purpose of the Study:
- To assess the efficacy of an exercise program in slowing the progression of dementia symptoms in early-onset dementia patients.
- To evaluate the impact of exercise on cognitive function, psychomotor speed, executive functioning, daily living activities, and quality of life.
Main Methods:
- 150 patients with early-onset dementia were recruited for the EXERCISE-ON study.
- Participants were randomized into either an aerobic exercise program or a flexibility and relaxation program, both conducted three times weekly for three months.
- A feasibility study involved participants engaging in a daily home-based physical activity program using pedometers for those living further from rehabilitation centers. Measurements were taken at baseline, three months, and six months.
Main Results:
- Primary outcomes measured include cognitive functioning, psychomotor speed, executive functioning, activities of daily living, and quality of life.
- Secondary outcomes encompass physical measures, neuropsychological assessments, and rest-activity rhythm.
- Data analysis is ongoing to determine the effects of the interventions on these outcomes.
Conclusions:
- The EXERCISE-ON study is pioneering in offering exercise programs specifically for patients with early-onset dementia.
- This research is expected to provide crucial evidence on the effects of exercise on early-onset dementia symptoms.
- Findings are anticipated to inform interventions aimed at improving the quality of life for individuals with early-onset dementia.
Related Concept Videos
01:26Exercise Stress Test
Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
01:20Exercise and Cardiovascular Response
Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
01:30Dementia
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
The progression of dementia is generally gradual.