Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage: a long-term time
Jie Sun1, Hunter R Underhill, Daniel S Hippe
1Department of Radiology, University of Washington, Seattle, WA, USA.
Insights
Intraplaque hemorrhage (IPH) in carotid arteries promotes plaque progression both immediately and long-term. Early identification of IPH is crucial for managing carotid atherosclerosis and preventing future complications.
Area of Science:
- Cardiovascular Research
- Neuroimaging
- Atherosclerosis Studies
Background:
- Intraplaque hemorrhage (IPH) is linked to faster carotid artery plaque progression.
- The precise time course and long-term impact of IPH on plaque burden remain unclear.
- Carotid MRI offers a noninvasive method for detecting IPH and quantifying plaque volume, validated against histology.
Purpose of the Study:
- To investigate the immediate and long-term effects of intraplaque hemorrhage (IPH) on carotid artery plaque progression.
- To determine the influence of IPH development on the rate of plaque growth over time.
Main Methods:
- Asymptomatic individuals with 50-79% carotid stenosis underwent serial MRI for 54 months.
- Subjects with IPH at 54 months were analyzed for IPH presence and wall volume changes at all time points.
- A linear mixed model analyzed piecewise progression curves to compare plaque growth rates before, during, and after IPH development.
Main Results:
- IPH development was associated with increased plaque progression rates.
- The progression rate during/after IPH (18.3 mm(3)/year) was significantly higher than before IPH (p=0.018).
- No ischemic events were observed in conjunction with new IPH during the study period.
Conclusions:
- Intraplaque hemorrhage (IPH) has both immediate and sustained effects on promoting carotid plaque progression.
- IPH appears to significantly alter the natural history and biological behavior of carotid atherosclerosis.
- Identifying patients with IPH early can optimize management strategies to mitigate adverse outcomes.
Objectives:
This study sought to determine the immediate and long-term effects of intraplaque hemorrhage (IPH) on plaque progression in the carotid artery.
Background:
Previous studies have associated IPH in the carotid artery with more rapid plaque progression. However, the time course and long-term effect remain unknown. Carotid magnetic resonance imaging is a noninvasive imaging technique that has been validated with histology for the accurate in vivo detection of IPH and measurement of plaque burden.
Methods:
Asymptomatic subjects with 50% to 79% carotid stenosis underwent carotid magnetic resonance imaging at baseline and then serially every 18 months for a total of 54 months. Subjects with IPH present in at least 1 carotid artery at 54 months were selected. Subsequently, presence/absence of IPH and wall volume were determined independently in all time points for both sides. A piece-wise progression curve was fit by using a linear mixed model to compare progression rates described as annualized changes in wall volume between periods defined by their relationship to IPH development.
Results:
From 14 subjects who exhibited IPH at 54 months, 12 arteries were found to have developed IPH during the study period. The progression rates were -20.5 ± 13.1, 20.5 ± 13.6, and 16.5 ± 10.8 mm(3)/year before, during, and after IPH development, respectively. The progression rate during IPH development tended to be higher than the period before (p = 0.080) but comparable to the period after (p = 0.845). The progression rate in the combined period during/after IPH development was 18.3 ± 6.5 mm(3)/year, which indicated significant progression (p = 0.008 compared with a slope of 0) and was higher than the period before IPH development (p = 0.018). No coincident ischemic events were noted for new IPH.
Conclusions:
The development of IPH posed an immediate and long-term promoting effect on plaque progression. IPH seems to alter the biology and natural history of carotid atherosclerosis. Early identification of patients with IPH may prove invaluable in optimizing management to minimize future sequelae.
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