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[Antioxidant status after surgical stress]
U Kreinhoff1, I Elmadfa, F Salomon
1Institut für Ernährungswissenschaft, Universität Giessen.
Infusionstherapie (Basel, Switzerland)
|October 1, 1990
Summary
Trauma and anesthesia induce catabolic metabolism and oxidative stress. Antioxidant systems are depleted, highlighting increased nutrient requirements during recovery.
Area of Science:
- Biochemistry
- Physiology
- Anesthesiology
Context:
- Trauma and anesthesia trigger significant metabolic and physiological changes.
- Hormonal responses drive a catabolic state, characterized by increased glycogenolysis, gluconeogenesis, proteolysis, and lipolysis.
- Oxidative stress, indicated by elevated lipid peroxidation, is a common consequence of trauma, surgery, and critical illness.
Purpose:
- To investigate the metabolic and oxidative stress responses in patients undergoing trauma or surgery.
- To assess the impact of anesthesia and artificial respiration on metabolic changes and free radical production.
- To evaluate the adaptive responses of enzymatic and non-enzymatic antioxidant systems to oxidative stress.
Summary:
- Patients in three groups (injured, pulmonary disease, multiple trauma) exhibited increased lipid peroxidation post-trauma or surgery.
- Stress factors, patient metabolism, anesthetics, and artificial respiration contribute to free radical production.
- Enzymatic antioxidant systems (superoxide dismutase, glutathione peroxidase, catalase) adapt positively, while non-enzymatic antioxidants (tocopherol, ascorbic acid, selenium) are depleted, suggesting increased demand.
Impact:
- Findings underscore the significant metabolic burden and oxidative stress associated with trauma and anesthesia.
- Highlights the crucial role of monitoring and potentially supplementing antioxidant systems in critically ill patients.
- Provides insights into the complex interplay between stress, metabolism, and antioxidant defense mechanisms in surgical and trauma patients.