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Updated: May 19, 2026

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model
Published on: February 8, 2022
Effects of acute intracranial hypertension on extracerebral organs: a randomized experimental study in pigs
Jan Florian Heuer1, Maren Selke, Thomas A Crozier
1Department of Anaesthesiology, Emergency and Intensive Care Medicine, University Hospital Göttingen, Göttingen, Germany. jheuer@med.uni-goettingen.de
Background:
The study was conducted to determine the effects of isolated acute intracranial hypertension (AICH) on extracerebral organs.
Design:
A total of 14 mechanically ventilated pigs were randomized to two groups of seven each: (1) control and (2) AICH.
Methods:
AICH was induced by inflating an intracranial balloon catheter. The inflation volume was adjusted to keep intracranial pressure between 30 and 40 cm H2O. Hemodynamics, gas-exchange, and global oxygen delivery parameters were observed over a 4-hour period. At the end of the 4-hour period, tissue samples of heart, lungs, liver, and kidneys were collected and histologically graded for inflammation, edema, and cell damage (necrosis) using semiquantitative scores.
Results:
Animals with AICH had increased heart rate and cardiac output, and higher scores for inflammation, edema, and necrosis in heart, lung, kidney, and liver tissues (all p < 0.05). Peripheral and mixed-venous oxygen saturations were unaffected.
Conclusions:
Isolated AICH induces injury to multiple extracerebral organs, even in the absence of hypoperfusion or hypoxemia.
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