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Updated: May 19, 2026
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A Microfluidic-based Electrochemical Biochip for Label-free DNA Hybridization Analysis
Published on: September 10, 2014
A proximity-dependent surface hybridization strategy for constructing an efficient signal-on electrochemical DNAzyme
Rong Hu1, Ting Fu, Xiao-Bing Zhang
1Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Chemical Communications (Cambridge, England)
|August 18, 2012
Abstract:
A proximity-dependent surface hybridization strategy is employed for designing a "signal-on" electrochemical DNAzyme biosensor. By taking advantage of the high sensitivity of the PDSH strategy, and by realizing the enzymatic hydrolysis reaction in a homogenous system with a unimolecular design, the proposed biosensor shows a very high sensitivity to target molecules.
