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Related Experiment Video

Updated: May 19, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

Published on: June 24, 2018

Remineralization models.

N J Cochrane¹, D T Zero, E C Reynolds

¹Oral Health Cooperative Research Centre, Melbourne Dental School, Bio 21 Institute, The University of Melbourne, Melbourne, Australia.

Advances in Dental Research

|August 18, 2012

Summary

This summary is machine-generated.

This study discusses remineralization models for caries research. While in situ models are valuable surrogates for clinical trials, they require validation and flexible designs with essential features for accurate caries process investigation.

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Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

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Published on: June 24, 2018

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Comprehensive Characterization of Tissue Mineralization in an Ex Vivo Model

Published on: September 27, 2024

Area of Science:

Dental research
Caries modeling
Biomineralization

Background:

Remineralization models are crucial for understanding caries progression.
The International Conference on Nanotechnology Research Applications (ICNARA 2) hosted a workshop on these models.
Current models require validation and refinement for reliable clinical trial surrogacy.

Purpose of the Study:

To summarize discussions on the role and design of remineralization models.
To identify essential features for in situ caries models.
To explore alternative caries models and emerging remineralization measurement techniques.

Main Methods:

Workshop discussion and summarization of expert opinions.
Review of existing in situ and alternative caries models.
Exploration of novel methods for quantifying remineralization.

Main Results:

In situ and other caries models can serve as clinical trial surrogates if validated.
In situ model design should be flexible yet incorporate essential features.
Various alternative models (non-cavitated, post-orthodontic, plaque retention, root caries) were discussed.
New remineralization quantification methods need validation before clinical use.

Conclusions:

Validated in situ models with flexible, feature-rich designs are valuable for caries research.
A diverse range of alternative models can address specific aspects of caries.
Further validation is necessary for new remineralization measurement techniques to be incorporated into clinical trials.