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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Tooth Anatomy01:21

Tooth Anatomy

The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
Assessment of the Mouth01:26

Assessment of the Mouth

A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Tooth agenesis: newer concept.

Meena Kulkarni1, Tripti Agrawal, Supriya Kheur

  • 1Department of Oral Pathology and Microbiology, Dr. DY Patil Dental College and Hospital, Pimpri Pune.

The Journal of Clinical Pediatric Dentistry
|August 21, 2012
PubMed
Summary
This summary is machine-generated.

Dental agenesis, a developmental disturbance, can be isolated or part of genetic syndromes. Identifying gene mutations is key to understanding and treating these conditions affecting child development.

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Last Updated: May 19, 2026

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Published on: April 13, 2022

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Area of Science:

  • Oral developmental biology
  • Human genetics
  • Pediatric dentistry

Background:

  • Developmental disturbances of the oral cavity impact child growth.
  • Tooth agenesis is a common condition, occurring alone or with syndromes.
  • Genetic factors, including gene signaling pathways and chromosomal defects, influence tooth development.

Purpose of the Study:

  • To conduct a comprehensive literature review of syndromic and nonsyndromic dental agenesis.
  • To identify and list various syndromes associated with dental agenesis.

Main Methods:

  • Literature review of scientific articles on dental agenesis.
  • Analysis of genetic factors, including gene mutations and signaling pathways.
  • Compilation of syndromes linked to tooth agenesis.

Main Results:

  • Dental agenesis can be isolated or associated with numerous genetic syndromes.
  • Chromosomal defects and gene mutations are implicated in the pathogenesis of dental agenesis.
  • Understanding genetic underpinnings is crucial for effective treatment strategies.

Conclusions:

  • Dental agenesis has diverse etiologies, ranging from isolated genetic variations to complex syndromes.
  • Genetic analysis aids in diagnosing and managing patients with dental agenesis.
  • Further research into gene-disease relationships can improve therapeutic outcomes.