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Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT
10:28

Gene Regulation and Targeted Therapy in Gastric Cancer Peritoneal Metastasis: Radiological Findings from Dual Energy CT and PET/CT

Published on: January 22, 2018

Retinoid receptors in gastric cancer: expression and influence on prognosis

Kong-Wang Hu1, Fei-Hu Chen, Jin-Fang Ge

  • 1Department of General Surgery, the First Hospital of Anhui Medical University, School of Pharmacology, Anhui Medical University, Hefei, China.

Asian Pacific Journal of Cancer Prevention : APJCP
|August 21, 2012
PubMed
Abstract

Insights

Retinoic acid receptors (RARs) are expressed in gastric cancer, with lower levels linked to advanced disease. High RARα expression indicates a better prognosis, supporting retinoid therapy for gastric cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Gastric cancer necessitates novel treatments due to high lethality.
  • Retinoids show promise in preventing gastric cancer cell differentiation, proliferation, and malignant transformation.
  • Retinoid receptors (RARs and RXRs) are transcription factors with known roles in cellular processes.

Purpose of the Study:

  • To investigate the expression of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) in gastric cancer.
  • To correlate receptor expression with clinical characteristics and patient prognosis.
  • To explore the therapeutic potential of retinoids in gastric cancer treatment.

Main Methods:

  • Immunohistochemistry was used to analyze RARα, RARβ, RARγ, RXRα, RXRβ, and RXRγ expression in 147 gastric cancers and 51 normal tissues.
  • Real-time PCR quantified retinoid receptor mRNA in gastric adenocarcinoma and normal tissues.
  • Clinical follow-up data were correlated with receptor expression, and outcomes for 80 patients treated with all-trans-retinoic acid (ATRA) were analyzed.

Main Results:

  • RARα, RARβ, RARγ, and RXRγ expression correlated positively and were lower in gastric carcinoma tissues.
  • Reduced RARβ, RARγ, and RXRα expression were linked to advanced tumor stages.
  • Low RARα expression correlated with significantly poorer overall survival, while ATRA treatment improved survival rates.

Conclusions:

  • Retinoic acid receptors are frequently expressed in gastric cancer, with a tendency for decreased expression.
  • RARα expression may serve as a positive prognostic indicator in gastric cancer.
  • This study provides a molecular rationale for using retinoids as a therapeutic strategy for gastric cancer.

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