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A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Post-stroke depression: an update

G Espárrago Llorca1, L Castilla-Guerra2, M C Fernández Moreno3

  • 1Servicio de Psiquiatría, Hospital de la Merced, Osuna, Sevilla, España.

Neurologia (Barcelona, Spain)
|August 21, 2012
PubMed

Insights

Post-stroke depression (PSD) affects one in three stroke survivors, often going undiagnosed and untreated. Early detection and treatment by neurologists are crucial for improving recovery and quality of life.

Area of Science:

  • Neurology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Post-stroke depression (PSD) is the most common mood disorder after stroke, significantly hindering patient recovery and rehabilitation.
  • PSD impacts up to one-third of stroke patients and is frequently undiagnosed or untreated, despite its association with increased mortality.
  • Pathogenesis involves biological, behavioral, and social factors, with symptoms manifesting early or late post-stroke.

Purpose of the Study:

  • To highlight the prevalence and impact of post-stroke depression (PSD).
  • To emphasize the importance of early detection and appropriate treatment strategies for PSD.
  • To underscore the critical role of neurologists in managing PSD.

Main Methods:

  • Review of current understanding of PSD pathogenesis, including biological, behavioral, and social factors.
  • Discussion of diagnostic approaches, recommending tools like the Patient Health Questionnaire-2 (PHQ-2).
  • Overview of recommended treatments, primarily selective serotonin reuptake inhibitors (SSRIs), while noting treatment uncertainties.

Main Results:

  • PSD is highly prevalent, with over half of cases remaining undiagnosed and untreated.
  • Early onset PSD is more common, presenting with symptoms like sleep disturbances and social withdrawal.
  • Selective serotonin reuptake inhibitors (SSRIs) are the primary treatment, though optimal timing and effects on function require further research.

Conclusions:

  • Neurologists are essential in identifying and managing PSD to improve patient outcomes.
  • Early detection and treatment of PSD can significantly enhance functional recovery and social reintegration.
  • Addressing PSD improves the quality of life for stroke survivors and their families.
Abstract

Keywords:
AntidepresivosAntidepressantsCerebrovascular diseaseDepresión post ictusEnfermedad cerebrovascularIctusInhibidores selectivos de la recaptación de serotoninaPost-stroke depressionSelective serotonin reuptake inhibitorsStroke

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