Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Post-traumatic Stress Disorder01:27

Post-traumatic Stress Disorder

Post-traumatic stress disorder (PTSD) is a psychiatric condition that arises following exposure to traumatic events such as natural disasters, forced displacement, or severe accidents. It significantly impairs individuals' ability to cope with daily activities and disrupts their emotional and psychological equilibrium.
Symptoms and Behavioral Manifestations
A spectrum of distressing symptoms characterizes PTSD. Recurrent flashbacks, where individuals involuntarily relive traumatic events, are a...
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of hypertension on stroke. Are there different age profiles?

Neurologia·2026
Same author

Impact of arterial hypertension on ocular vascular ischemia.

Revista clinica espanola·2025
Same author

Positioning for the use of multivessel clinicalultrasound in vascular risk evaluation: VASUS+protocol. 2024 Recommendations of the Vascular Risk WorkingGroup of The Spanish Society of Internal Medicine (SEMI), Clinical Ultrasound Working Group of the Spanish Society of Internal Medicine (SEMI) and the Spanish Society of Hypertension-Spanish League for the Fight against Arterial Hypertension (SHE-LELHA).

Revista clinica espanola·2025
Same author

Positioning for the use of multivessel clinical ultrasound in vascular risk evaluation: VASUS+ protocol. 2024 recommendations of the Vascular Risk Group, clinical ultrasound of the Spanish Society of Internal Medicine and Spanish Society of Hypertension and Vascular Risk.

Hipertension y riesgo vascular·2025
Same author

Importance of blood pressure monitoring in the acute phase of stroke. An update.

Hipertension y riesgo vascular·2024
Same author

[Importance of hypertension in patients after the first stroke: retrospective cohort study].

Hipertension y riesgo vascular·2023

Related Experiment Video

Updated: May 19, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Post-stroke depression: an update.

G Espárrago Llorca1, L Castilla-Guerra2, M C Fernández Moreno3

  • 1Servicio de Psiquiatría, Hospital de la Merced, Osuna, Sevilla, España.

Neurologia (Barcelona, Spain)
|August 21, 2012
PubMed
Summary
This summary is machine-generated.

Post-stroke depression (PSD) affects one in three stroke survivors, often going undiagnosed and untreated. Early detection and treatment by neurologists are crucial for improving recovery and quality of life.

Keywords:
AntidepresivosAntidepressantsCerebrovascular diseaseDepresión post ictusEnfermedad cerebrovascularIctusInhibidores selectivos de la recaptación de serotoninaPost-stroke depressionSelective serotonin reuptake inhibitorsStroke

Related Experiment Videos

Last Updated: May 19, 2026

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats
04:38

A Middle Cerebral Artery Occlusion Technique for Inducing Post-stroke Depression in Rats

Published on: May 22, 2019

Area of Science:

  • Neurology
  • Psychiatry
  • Rehabilitation Medicine

Background:

  • Post-stroke depression (PSD) is the most common mood disorder after stroke, significantly hindering patient recovery and rehabilitation.
  • PSD impacts up to one-third of stroke patients and is frequently undiagnosed or untreated, despite its association with increased mortality.
  • Pathogenesis involves biological, behavioral, and social factors, with symptoms manifesting early or late post-stroke.

Purpose of the Study:

  • To highlight the prevalence and impact of post-stroke depression (PSD).
  • To emphasize the importance of early detection and appropriate treatment strategies for PSD.
  • To underscore the critical role of neurologists in managing PSD.

Main Methods:

  • Review of current understanding of PSD pathogenesis, including biological, behavioral, and social factors.
  • Discussion of diagnostic approaches, recommending tools like the Patient Health Questionnaire-2 (PHQ-2).
  • Overview of recommended treatments, primarily selective serotonin reuptake inhibitors (SSRIs), while noting treatment uncertainties.

Main Results:

  • PSD is highly prevalent, with over half of cases remaining undiagnosed and untreated.
  • Early onset PSD is more common, presenting with symptoms like sleep disturbances and social withdrawal.
  • Selective serotonin reuptake inhibitors (SSRIs) are the primary treatment, though optimal timing and effects on function require further research.

Conclusions:

  • Neurologists are essential in identifying and managing PSD to improve patient outcomes.
  • Early detection and treatment of PSD can significantly enhance functional recovery and social reintegration.
  • Addressing PSD improves the quality of life for stroke survivors and their families.