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Related Experiment Videos

Tissue specific expression of mouse transferrin during development and aging.

F M Yang1, W E Friedrichs, J M Buchanan

  • 1Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.

Mechanisms of Ageing and Development
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

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This study identifies tissue-specific expression of the transferrin (TF) gene in mice across development and aging. Liver TF mRNA levels show cyclic variations, highlighting dynamic gene regulation during development and aging.

Area of Science:

  • Developmental Biology
  • Gene Expression Regulation
  • Mammalian Physiology

Background:

  • Transferrin (TF) is a crucial plasma protein responsible for iron transport.
  • Understanding tissue-specific TF gene expression is vital for comprehending iron homeostasis.
  • Dynamic regulation of TF is implicated in various physiological processes.

Purpose of the Study:

  • To investigate the tissue-specific expression patterns of the transferrin gene in mice.
  • To analyze TF gene expression during embryonic development, maturity, and aging.
  • To identify periods of dynamic regulatory changes in TF gene expression.

Main Methods:

  • Quantitative analysis of transferrin mRNA expression in various mouse tissues.
  • Monitoring TF gene expression across different developmental stages (gestation, maturity, aging).

Related Experiment Videos

  • Utilizing mouse models, including fetal tissues and macrophage cell lines.

    • Main Results:

    • Transferrin gene expression is prominent in mouse liver, cerebral hemispheres, and cerebellum.
    • TF mRNA is detected in fetal lung, heart, stomach, and kidney at 19 days of gestation.
    • Liver TF mRNA levels exhibit cyclic variations during development and aging, increasing with age.

    Conclusions:

    • The transferrin gene exhibits dynamic, tissue-specific expression patterns throughout the mouse lifespan.
    • These findings provide insights into the regulatory mechanisms of the TF gene in vivo.
    • The study designates critical periods for TF gene regulation during development and aging.