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Updated: May 19, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Pulmonary echography in systemic sclerosis.

F C Moazedi-Fuerst¹, P M Zechner, N J Tripolt

¹Division of Rheumatology and Immunology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. florentine.fuerst@medunigraz.at

Clinical Rheumatology

|August 21, 2012

Summary

This summary is machine-generated.

Lung ultrasound shows promise for early detection of interstitial lung disease (ILD) in systemic sclerosis (SSc) patients. This noninvasive method may help screen for pulmonary changes, complementing traditional imaging techniques.

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Published on: December 12, 2025

Area of Science:

Pulmonology
Rheumatology
Medical Imaging

Background:

Systemic sclerosis (SSc) is associated with high mortality, particularly due to interstitial lung disease (ILD) and pulmonary hypertension.
Early detection of pulmonary manifestations in SSc is crucial for patient outcomes.
High-resolution computed tomography (HRCT) is the current gold standard for ILD diagnosis, but lung ultrasound offers a noninvasive, radiation-free alternative.

Purpose of the Study:

To evaluate the reliability of lung sonography for assessing pulmonary structural changes in patients with systemic sclerosis.
To compare sonographic findings with HRCT results in SSc patients.
To explore the potential of lung ultrasound as a screening tool for early ILD detection in SSc.

Main Methods:

A pilot study involving 25 SSc patients and 40 healthy volunteers.
Screening of pleura and pulmonary parenchyma using lung sonography, scoring B lines, comet tail phenomena, and pleural irregularities.
All SSc patients underwent chest HRCT for ILD diagnosis confirmation.

Main Results:

Forty-four percent of SSc patients exhibited B line phenomena and pleural thickening, consistent with ILD confirmed by HRCT.
B line phenomena and pleural irregularities were significantly more prevalent in SSc patients compared to controls.
SSc patients with confirmed ILD showed higher pleural and comet scores on lung ultrasound than those without radiographic ILD.

Conclusions:

Lung sonography demonstrates potential as a reliable, noninvasive method for screening SSc patients for early pulmonary structural changes.
Sonographic findings like B lines and pleural irregularities correlate with ILD diagnosis in SSc.
Further validation in larger studies is warranted to establish transthoracic lung ultrasound as a standard screening tool for SSc-related lung disease.