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Updated: May 19, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium-assisted regioselective C-H cyanation of heteroarenes using isonitrile as cyanide source
Shuguang Xu1, Xiaomei Huang, Xiaohu Hong
1Department of Chemistry, Shanghai University, Shanghai 200444, China.
Abstract:
A palladium-catalyzed regioselective C-H cyanation of heteroarenes was achieved using tert-butyl isocyanide as "CN" source, which provides a new and unique strategy for the preparation of (hetero)aryl nitriles. Indoles, pyrroles, and aromatic rings could be efficiently cyanated through C-H bond activation with high regioselectivity.
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