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Updated: May 19, 2026
07:22
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
Published on: March 14, 2025
[How to treat systemic necrotizing vasculitides?]
1AP-HP, hôpital Cochin, université Paris-Descartes, Sorbonne Paris Cité, service de médecine interne, Inserm 1016, 75014 Paris, France. loic.guillevin@cch.aphp.fr
Presse Medicale (Paris, France : 1983)
|August 22, 2012
Summary
Systemic necrotizing vasculitis treatments include corticosteroids and cytotoxic agents, aiming for remission. Maintenance therapy and newer biologics like rituximab help manage high relapse rates in this condition.
Area of Science:
- Rheumatology
- Immunology
Context:
- Systemic necrotizing vasculitides (SNVs) are serious autoimmune diseases.
- Treatment typically involves corticosteroids and cytotoxic agents for at least 18 months.
Purpose:
- To outline current treatment strategies for SNVs.
- To discuss remission rates, relapse, and maintenance therapies.
Summary:
- Corticosteroids and cytotoxic agents are standard SNV treatments.
- Remission is achieved in about 90% of patients, but relapse rates are high.
- Maintenance therapy (azathioprine, methotrexate) and biologics (rituximab) are crucial.
Impact:
- Provides an overview of SNV management.
- Highlights the importance of long-term treatment and newer therapeutic options like rituximab.
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