Related Experiment Videos
Management of radiation maculopathy.
Arun D Singh1, Sheila Pabon, Mary E Aronow
1Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA. singha@ccf.org
Ophthalmic Research
|August 22, 2012
Summary
Radiation maculopathy, a complication of radiation exposure, is influenced by dose. Prevention strategies, like periocular steroids, may be more effective than current anti-VEGF treatments for radiation maculopathy.
Area of Science:
- Ophthalmology
- Radiation Oncology
- Medical Complications
Background:
- Radiation maculopathy is a delayed complication following radiation exposure.
- Risk factors include host and radiation parameters, with total dose to the macula being key.
- Clinical presentation varies due to damage across multiple ocular tissues.
Purpose of the Study:
- To review the understanding of radiation maculopathy.
- To evaluate current treatment efficacy and explore preventative strategies.
- To highlight the need for improved radiation delivery techniques.
Main Methods:
- Literature review of radiation maculopathy.
- Analysis of risk factors and progression.
- Assessment of current therapeutic interventions (anti-VEGF) and preventative measures (periocular steroids).
Main Results:
- Total radiation dose is the most critical modifiable factor.
- Current anti-VEGF treatments provide only short-term, modest visual improvement.
- Periocular steroid use during plaque brachytherapy shows short-term preventative potential.
Conclusions:
- Prevention of radiation maculopathy is paramount.
- Newer radiation delivery designs and techniques are needed.
- Further research into effective, long-term management and prevention is essential.
Related Concept Videos
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...