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Updated: May 19, 2026
06:03
Orthotopic Transplantation of Syngeneic Lung Adenocarcinoma Cells to Study PD-L1 Expression
Published on: January 19, 2019
Transplantation for lung cancer.
Tiago N Machuca1, Shaf Keshavjee
1Division of Thoracic Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Current Opinion in Organ Transplantation
|August 22, 2012
Summary
Lung transplantation (LTx) is increasingly considered for select lung cancer cases when other treatments fail. Careful patient selection and staging are crucial for successful outcomes in malignant disease management.
Area of Science:
- Cardiology
- Oncology
- Pulmonology
Background:
- Lung transplantation outcomes have improved, with increasing annual procedures.
- Lung transplantation for lung cancer is a growing, albeit controversial, area.
Purpose of the Study:
- To review the role of lung transplantation in managing malignant diseases.
- To discuss challenges in managing incidental lung cancer found in explanted lungs.
Main Methods:
- Review of International Society for Heart and Lung Transplantation Registry data.
- Analysis of current literature on lung transplantation for malignant conditions.
Main Results:
- Lung transplantation may be considered for specific lung cancer scenarios unresponsive to other treatments.
- Careful patient selection and staging are critical for acceptable results.
- Prognosis for incidental lung cancer post-transplant depends on malignancy stage.
Conclusions:
- Lung transplantation can achieve results comparable to non-neoplastic indications for selected malignant diseases.
- Advanced staging modalities like endobronchial ultrasound and PET scans are recommended to refine patient selection.
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