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Updated: Sep 3, 2025
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Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
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Statin Use May Be Associated With a Lower Risk of Invasive Aspergillosis in Lung Transplant Recipients
Armelle Pérez-Cortés Villalobos1,2, Farid Foroutan1, Setareh Davoudi1
1Transplant Infectious Diseases, Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada.
Summary
Statins significantly reduced the risk of invasive aspergillosis (IA) in lung transplant recipients (LTRs). This study found statin use was associated with a 70% risk reduction for IA in LTRs.
Area of Science:
- Cardiology
- Infectious Diseases
- Transplantation Medicine
Background:
- Statins inhibit HMG-CoA reductase, crucial for cholesterol and ergosterol synthesis.
- The impact of statins on invasive aspergillosis (IA) risk in lung transplant recipients (LTRs) is not well-established.
Purpose of the Study:
- To investigate the association between statin use and the risk of developing invasive aspergillosis (IA) in lung transplant recipients (LTRs).
Main Methods:
- Retrospective analysis of LTRs from 2010-2017, followed for one year post-transplant.
- Diagnosis of IA followed ISHLT criteria.
- Multivariable Cox proportional hazards model used to assess statin use association with IA risk, adjusting for known risk factors.
Main Results:
- Out of 785 LTRs, 57% received statins; 7% developed IA within one year.
- Statin use was independently associated with a significantly lower risk of IA (SHR 0.30, P = .002).
- Statin use also correlated with a lower incidence of post-transplant Aspergillus colonization.
Conclusions:
- Statin use for at least two weeks in the first year post-transplant was linked to a 70% reduction in IA risk among LTRs.
- Findings suggest a potential protective role of statins against IA in LTRs.
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