The capacity, capabilities and needs of the WHO BioDoseNet member laboratories

Area of Science:

• Radiation biology
• Public health
• Medical countermeasures

Background:

• Biodosimetry is vital for assessing radiation exposure, especially during mass casualty incidents when physical dosimetry is unreliable.
• The dicentric chromosome assay is the gold standard for biodosimetry but faces throughput limitations in emergency scenarios.
• Many nations have developed cytogenetic biodosimetry expertise and regional networks for emergency response.

Purpose of the Study:

• To evaluate the global capacity of cytogenetic biodosimetry laboratories within the World Health Organization's BioDoseNet network.
• To identify expertise, in vivo experience, and involvement in national/international activities among member laboratories.
• To understand the challenges, needs, and future prospects of emergency cytogenetic biodosimetry.

Main Methods:

• An in-depth survey was conducted among BioDoseNet member laboratories.
• The survey collected data on laboratory capabilities, personnel expertise, and operational experience.
• Data analysis focused on assessing current emergency cytogenetic biodosimetry readiness.

Main Results:

• The survey provides a comprehensive overview of the global state of emergency cytogenetic biodosimetry.
• Significant information was gathered on the existing capacity, expertise, and challenges faced by laboratories worldwide.
• Results highlight the current capabilities and areas for development within the BioDoseNet network.

Conclusions:

• The survey results are crucial for understanding and enhancing global preparedness for radiation emergencies.
• Findings will inform strategies for strengthening international collaboration and capacity building in biodosimetry.
• The data supports the optimization of the BioDoseNet network for effective radiation incident response.