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Published on: August 14, 2019
Anticomplement and antimicrobial activities of flavonoids from Entada phaseoloides
Ke Li1, Shihua Xing, Mengyue Wang
1School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, PR China.
Natural Product Communications
|August 23, 2012
Summary
Flavonoids from Entada phaseoloides stems show anticomplement and antimicrobial effects. Quercetin, luteolin, and galangin were particularly effective against specific bacteria and complement pathways.
Area of Science:
- Phytochemistry
- Pharmacology
- Microbiology
Background:
- Entada phaseoloides is a plant species with potential medicinal properties.
- Flavonoids are a class of natural compounds known for diverse biological activities.
- The stem of Entada phaseoloides has not been previously investigated for its bioactivities.
Purpose of the Study:
- To isolate and identify flavonoids from Entada phaseoloides stem extracts.
- To evaluate the anticomplement activity (classic and alternative pathways) of these flavonoids.
- To assess the antimicrobial activity against various bacteria and a pathogenic fungus.
Main Methods:
- Seventeen flavonoids were isolated from Entada phaseoloides stem extracts.
- Anticomplement activity was tested against both classic and alternative pathways.
- Antimicrobial activity was evaluated against Gram-positive bacteria (MRSA, MSSA, Enterococcus, Bacillus subtilis), Gram-negative bacteria (Escherichia coli, Pseudomonas aeuroginosa), and Candida albicans.
Main Results:
- Several isolated flavonoids, including quercetin, luteolin, and apigenin, demonstrated dose-dependent anticomplement activity.
- Quercetin, 5,7,4'-trihydroxy-3'-methoxyflavonol, and galangin inhibited MRSA, MSSA, and Standard Enterococcus.
- Luteolin and rhamnocitrin showed inhibitory activity against MRSA and MSSA.
Conclusions:
- The stem of Entada phaseoloides contains flavonoids with significant anticomplement and antimicrobial properties.
- This study provides the first report on the anticomplement and antimicrobial activities of Entada phaseoloides stem extracts.
- The identified flavonoids, particularly quercetin, luteolin, and galangin, represent potential candidates for further therapeutic development.
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