Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antifungal Agents

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Atmospheric oxidation of 1,3-butadiene: influence of seed aerosol acidity and relative humidity on SOA composition and the production of air toxic compounds.

Atmospheric chemistry and physics·2025

Same author

Relative rates of addition of carbanions to substituted nitroarenes: can quantum chemical calculations give meaningful predictions?

Physical chemistry chemical physics : PCCP·2025

Same author

Gold-Catalyzed 1,2-Aryl Shift and Double Alkyne Benzannulation.

Angewandte Chemie (International ed. in English)·2023

Same author

Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis.

The Biochemical journal·2023

Same author

New synthetic pathway leading to oxospirochlorins.

RSC advances·2022

Same author

Selective Impedimetric Chemosensing of Carcinogenic Heterocyclic Aromatic Amine in Pork by dsDNA-Mimicking Molecularly Imprinted Polymer Film-Coated Electrodes.

Journal of agricultural and food chemistry·2021

Same journal

Augmentation of Docetaxel-Induced Cytotoxicity in Human PC-3 Androgen-Independent Prostate Cancer Cells by Combination With Four Natural Apoptosis-Inducing Anticancer Compounds.

Natural product communications·2023

Same journal

Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells.

Natural product communications·2023

Same journal

Phytochemical characterization and bioactivity toward breast cancer cells of unhydrolyzed and acid-hydrolyzed extracts of <i>Fagonia indica</i>.

Natural product communications·2022

Same journal

PQQ Supplementation and SARS-CoV-2 Spike Protein-Induced Heart Inflammation.

Natural product communications·2022

Same journal

Prediction the Molecular Mechanism of Shengmai Injection in Acute Treatment of COVID-19 Based on Network Pharmacology.

Natural product communications·2022

Same journal

<i>Oroxylum indicum</i> extract, at a physiologically relevant dosage, does not induce hepatotoxicity in C57BL/6J mice.

Natural product communications·2021

See all related articles

Search research articles

Related Experiment Video

Updated: May 19, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Search for bioactive compounds from Cantharellus cibarius.

Włodzimierz Maria Daniewski¹, Witold Danikiewicz, W Marek Gołebiewski

¹lnstitute of Organic Chemistry, Polish Academy of Science, Kasprzaka 44/52, 01-224 Warsaw, Poland.

Natural Product Communications

|August 23, 2012

Summary

This summary is machine-generated.

Chanterelle mushrooms contain unique compounds like glycerol dilinoleates and tridehydrocrepenynate. These isolated compounds showed lower insecticidal activity than crude extracts, suggesting synergistic effects in the natural mixture.

More Related Videos

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Related Experiment Videos

Last Updated: May 19, 2026

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries

Published on: March 31, 2021

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products

Published on: December 5, 2020

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Cellular Membrane Affinity Chromatography Columns to Identify Specialized Plant Metabolites Interacting with Immobilized Tropomyosin Kinase Receptor B

Published on: January 19, 2022

Area of Science:

Natural Product Chemistry
Mycology
Insect Toxicology

Background:

Cantharellus cibarius (chanterelle) is a widely consumed mushroom with potential bioactive compounds.
Understanding the chemical composition and bioactivity of mushrooms is crucial for potential applications.
Previous research has explored various mushroom species for their medicinal and insecticidal properties.

Purpose of the Study:

To isolate and identify specific compounds from the fruit bodies of Cantharellus cibarius.
To evaluate the insecticidal activity of the isolated compounds and compare it to crude extracts.
To investigate potential synergistic effects among compounds in the mushroom extract.

Main Methods:

Extraction of ground chanterelle fruit bodies using dichloromethane, ethanol, and methanol.
Isolation of compounds using column chromatography (CC) and preparative high-performance liquid chromatography (HPLC).
Identification of isolated compounds including glycerol dilinoleates and glycerol tridehydrocrepenynate.
Assessment of insecticidal activity of isolated glycerides, esters, crude extracts, and fractions.

Main Results:

Glycerol 1,2- and 1,3-dilinoleates and glycerol tridehydrocrepenynate were isolated from dichloromethane extract.
Fatty acid ethyl or methyl esters were obtained from ethanol or methanol extracts.
Isolated glycerides and esters exhibited significantly lower insecticidal activity compared to crude extracts and chromatographic fractions.

Conclusions:

The insecticidal properties of Cantharellus cibarius are likely due to a synergistic interaction of multiple compounds rather than individual isolated substances.
Further research is needed to elucidate the specific synergistic mechanisms and identify all active components.
This study highlights the complexity of natural product bioactivity and the importance of evaluating mixtures.