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Interstitial granulomatous dermatitis associated with chronic inflammatory demyelinating polyneuropathy
Hobart W Walling1, Brian L Swick
1Town Square Dermatology, 1100 6th St, Ste 202, Coralville, IA 52241, USA. hobartwalling@yahoo.com
Cutis
|August 23, 2012
Summary
A man with chronic inflammatory demyelinating polyneuropathy developed itchy skin plaques. Interstitial granulomatous dermatitis was diagnosed and treated successfully with dapsone.
Area of Science:
- Dermatology
- Neurology
Background:
- Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disorder affecting peripheral nerves.
- Skin manifestations can occur in patients with CIDP, but are not well-characterized.
Observation:
- A 44-year-old man with a 3-year history of CIDP presented with a 6-month history of pruritic erythematous plaques on his lower extremities.
- The lesions were unresponsive to standard treatments like antifungal cream and topical corticosteroids.
Findings:
- Skin biopsy revealed a superficial and deep perivascular and interstitial lymphohistiocytic infiltrate with abundant neutrophils.
- The patient was diagnosed with interstitial granulomatous dermatitis (IGD).
Implications:
- This case highlights a potential association between CIDP and IGD.
- Oral dapsone demonstrated efficacy in treating the skin eruption, suggesting its utility in managing this specific presentation of IGD.
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