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Related Experiment Video

Updated: May 19, 2026

A Method for Investigating Age-related Differences in the Functional Connectivity of Cognitive Control Networks Associated with Dimensional Change Card Sort Performance
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Published on: May 7, 2014

Normal aging modulates prefrontoparietal networks underlying multiple memory processes.

Fabio Sambataro1, Martin Safrin, Herve S Lemaitre

  • 1Brain Center for Motor and Social Cognition, Istituto Italiano di Tecnologia, 43100 Parma, Italy. fabio.sambataro@iit.it

The European Journal of Neuroscience
|August 23, 2012
PubMed
Summary
This summary is machine-generated.

Cognitive aging affects memory networks. Older adults show increased prefrontal cortex activation and broader network engagement, suggesting reduced brain specialization for memory tasks.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuroimaging

Background:

  • Cognitive aging is characterized by functional decline in memory-related brain regions.
  • While age-related memory differences are known, network-level effects across multiple memory types remain understudied.

Purpose of the Study:

  • To investigate age-related differences in brain activity and functional covariance across working memory and episodic encoding tasks.
  • To explore how aging impacts brain networks common to multiple memory processes.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed in younger and older adults.
  • Participants performed both working memory and incidental episodic encoding tasks.

Main Results:

  • Older adults exhibited increased left dorsolateral prefrontal cortex activation and reduced posterior cingulate deactivation.
  • Greater functional covariance was observed in older adults within prefronto-parietal-occipital and default mode networks.
  • These patterns suggest increased, process-invariant recruitment of prefronto-parietal-occipital networks with aging.

Conclusions:

  • Aging is associated with increased recruitment of widespread brain networks for memory processing.
  • Findings support the dedifferentiation hypothesis, indicating decreased specialization of brain networks in older adults.
  • This suggests a shift towards less distinct neural representations for different memory functions with advancing age.