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Preparation of Mycobacterium tuberculosis Culture Filtrate to Understand TB Pathogenesis
Published on: March 28, 2025
Early secretory antigenic target-6 of Mycobacterium tuberculosis: enigmatic factor in pathogen-host interactions
Ramesh Chandra Rai1, Ved Prakash Dwivedi, Samit Chatterjee
1Immunology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.
Microbes and Infection
|August 23, 2012
Abstract:
T helper (Th) 1 and 17 cells play important roles in host protective responses against tuberculosis. Early Secretory Antigenic Target 6; a Region of Difference 1 (RD1) encoded protein, mounts Th17-responses in the lung. Therefore, lack of RD-1 region makes Bacillus Calmette-Guérin (BCG) less vaccine efficacious than parent strains.

