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Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
Heart failure and mechanical circulatory support
Stephen Andrew Esper1, Kathirvel Subramaniam
1Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
Insights
Cardiovascular disease (CVD) is a major global health concern, significantly impacting Europe and the USA. This review focuses on congestive heart failure (HF), exploring its epidemiology, pathophysiology, and therapeutic options for anesthesiologists.
Area of Science:
- Cardiology and Anesthesiology
- Public Health and Epidemiology
Background:
- Cardiovascular disease (CVD) is a leading cause of morbidity and mortality globally, representing a significant disease burden in Europe and the USA.
- Congestive heart failure (HF) is a prevalent condition requiring increased attention, particularly in perioperative and intensive care settings.
Purpose of the Study:
- To review the epidemiology, pathophysiology, and current therapies for congestive heart failure (HF).
- To provide anesthesiologists with an understanding of HF management, including mechanical circulatory support and heart transplantation.
Main Methods:
- Literature review of cardiovascular disease (CVD) and congestive heart failure (HF) epidemiology and pathophysiology.
- Analysis of established and emerging therapies for end-stage HF, including mechanical circulatory assistance and heart transplantation.
Main Results:
- Cardiovascular disease (CVD) affects millions worldwide, with heart failure (HF) being a major component.
- Mechanical circulatory assistance and heart transplantation are key treatments for end-stage HF, with specific indications and contraindications.
Conclusions:
- Anesthesiologists increasingly encounter patients with heart failure (HF), necessitating comprehensive knowledge of the condition and its management.
- Understanding the efficacy, safety, and cost of circulatory support therapies is crucial for optimizing patient care in advanced HF.
Abstract:
Cardiovascular disease (CVD) is defined as one of the following: hypertension, congestive heart failure (HF), stroke, coronary heart disease and congenital heart defects. CVD is the main cause of the disease burden (illness and death) in Europe (23% of all the disease burdens) and the second main cause of the disease burden in those European Union (EU) countries with very low child and adult mortality (17%).(1) Heart disease is a common health problem worldwide. According to the most recent Heart Disease and Stroke Statistics-2011 update,(2) greater than 82 000 000 adults living in the United States of America (USA) have one or more types of CVD. Many resources have been invested in attempting to understand and curtail the progression of congestive HF. This article attempts to address the growing concern over HF by looking at the epidemiology, pathophysiology and available therapies as anaesthesiologists encounter these patients more often nowadays in the operating room and intensive care units. Mechanical circulatory assistance and heart transplantation are two established treatment methods for end-stage HF. In this review, we also address the indications and contraindications for mechanical circulatory assistance, types and spectrum of available ventricular assist devices, efficacy, safety and cost analysis of circulatory support therapy.
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